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Graduate School of Biomedical Sciences

Recent Publications from the Garlick Lab

Pastar I, Marjanovic J, Liang L, Stone RC, Kashpur O, Jozic I, Head CR, Smith A, Gerami-Naini B, Garlick JA, Tomic-Canic M. 2021. Cellular reprogramming of diabetic foot ulcer fibroblasts triggers pro-healing miRNA-mediated epigenetic signature. Exp Dermatol. Jun 11. doi: 10.1111/exd.14405. Abstract

Orzalli MH, Prochera A, Payne L, Smith A, Garlick JA, Kagan JC. 2021. Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells. Immunity. 5:S1074-7613(21)00174-6. doi: 10.1016/j.immuni.2021.04.012. Abstract

Santarella F, O'Brien FJ, Garlick JA, Kearney CJ. 2021. The development of tissue engineering scaffolds using matrix from iPS-reprogrammed fibroblasts. Methods Mol Biol. Mar 24. doi: 10.1007/7651_2021_351. Abstract

Marinkovic M, Sridharan R, Santarella F, Smith A, Garlick JA, Kearney CJ. 2021. Optimization of extracellular matrix production from human induced pluripotent stem cell-derived fibroblasts for scaffold fabrication for application in wound healing. J Biomed Mater Res A. 23. doi: 10.1002/jbm.a.37173. Abstract

Smith A, Watkins T, Theocharidis G, Lang I, Leschinsky M, Maione A, Kashpur O, Raimondo T, Rahmani S, Baskin J, Mooney DJ, Veves A, Garlick J. 2021. A novel 3D skin disease model to assess macrophage function in diabetes.Tissue Eng Part C Methods 27: 49-58. Abstract

Santarella F, Simpson CR, Lemoine M, McGrath S, Cavanagh B, Smith A, Murphy CM, Garlick JA, O'Brien FJ, Kearney CJ. 2021. The lubricating effect of iPS-reprogrammed fibroblasts on collagen-GAG scaffolds for cartilage repair applications. J Mech Behav Biomed Mater. 114: 104174. Abstract

LeClair AM, Kotzias V, Garlick J, Cole AM, Kwon SC, Lightfoot A, Concannon TW. 2020. Facilitating stakeholder engagement in early stage translational research. PLoS One. 15: e0235400. doi: 10.1371/journal.pone.0235400. Abstract

Santarella F, Sridharan R, Marinkovic M, Do Amaral RJFC, Cavanagh B, Smith A, Kashpur O, Gerami-Naini B, Garlick JA, O'Brien FJ, Kearney CJ. 2020. Scaffolds functionalized with matrix from induced pluripotent stem cell fibroblasts for diabetic wound healing. Adv Healthc Mater. 29:e2000307. doi: 10.1002/adhm.202000307. Abstract

Smith AE, Huang M, Watkins T, Burguin F, Baskin J, Garlick J. 2020. De novo production of human extracellular matrix supports increased throughput and cellular complexity in 3D skin equivalent model. J Tissue Eng Regen Med. 14: 1019-1027. Abstract

Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD III, Pioli PA, Whitfield ML, Garlick J. 2020. Systemic sclerosis dermal fibroblasts induce cutaneous fibrosis through lysyl oxidase-like 4: New evidence from three-dimensional skin-like tissues  Arthritis Rheumatol. 72: 791-801. Abstract

Huang M, Liu Z, Baugh L, DeFuria J, Maione A, Smith A, Kashpur O, Black III LD, Georgakoudi I, Whitfield ML, Garlick J. 2019. Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues. Lab Invest. 99: 514-527. Abstract

Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. 2018. An antiviral branch of the IL-1 signaling pathway restricts immune-evasive virus replication. Mol Cell 71: 825-840. Abstract

Kashpur O, Smith A, Gerami-Naini B, Maione AG, Calabrese R, Tellechea A, Theocharidis G, Liang L, Pastar I, Tomic-Canic M, Mooney D, Veves A, Garlick JA. 2018. Differentiation of diabetic foot ulcer-derived induced pluripotent stem cells reveals distinct cellular and tissue phenotypes. FASEB J 33: 1262-1277. Abstract

Garlick JA, Levine P. 2017. Where civics meets science: building science for the public good through Civic Science. Oral Dis. 23: 692-696. Abstract

Chen CO, Smith A, Liu Y, Du P, Blumberg JB, Garlick J. 2017. Photoprotection by pistachio bioactives in a 3-dimensional human skin equivalent tissue model. Int J Food Sci Nutr. 25: 1-9. Abstract

Higgins CA, Roger M, Hill R, Ali-Khan AS, Garlick J, Christiano AM, Jahoda CA. 2017. Multifaceted role of hair follicle dermal cells in bioengineered skins. Br J Dermatol. 176: 1259-1269. Abstract

Liang L, Stone RC, Stojadinovic O, Ramirez H, Pastar I, Maione AG, Smith A, Yanez V, Veves A, Kirsner RS, Garlick JA, Tomic-Canic M. 2016. Integrative analysis of miRNA and mRNA paired expression profiling of primary fibroblast derived from diabetic foot ulcers reveals multiple impaired cellular functions. Wound Regen Repair 24: 943-953.  Abstract

Garlick J, Levine P. 2016. Where civics meets science: Building science for the public good through civic science. Oral Dis. Epub ahead of print. Abstract

Gerami-Naini B, Smith A, Maione AG, Kashpur O, Carpinito G, Veves A, Mooney DJ, Garlick JA. 2016. Generation of induced pluripotent stem sells from diabetic foot ulcer fibroblasts using a nonintegrative Sendai virus. Cell Reprogram. 18: 214-223. Abstract

Maione AG, Smith A, Kashpur O, Yanez V, Knight E, Mooney DJ, Veves A, Tomic-Canic M, Garlick JA. 2016. Altered ECM deposition by diabetic foot ulcer-derived fibroblasts implicates fibronectin in chronic wound repair. Wound Repair Regen. 24: 630-643.  Abstract

Ramirez HA, Liang L, Pastar I, Rosa AM, Stojadinovic O, Zwick TG, Kirsner RS, Maione AG, Garlick JA, Tomic-Canic M. 2015. Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin. PLoS One 10 : e0137133.  Abstract

Park LK, Maione AG, Smith A, Gerami-Naini B, Iyer LK, Mooney DJ, Veves A, Garlick JA. 2014. Genome-wide DNA methylation analysis identifies a metabolic memory profile in patient-derived diabetic foot ulcer fibroblasts. Epigenetics 9: 1339-1349. Abstract

Hewitt KJ, Shamis Y, Gerami-Naini B, Garlick JA. 2014. Strategies for oral mucosal repair by engineering 3D tissues with pluripotent stem cells. Adv Wound Care 3: 742-750.  Abstract

Maione AG, Brudno Y, Stojadinovic O, Park LK, Smith A, Tellechea A, Leal EC, Kearney CJ, Veves A, Tomic-Canic M, Mooney D, Garlick J. 2014. 3D human tissue models that incorporate diabetic foot ulcer-derived fibroblasts mimic in vivo features of chronic wounds. Tissue Eng Part C Methods 21: 499-508.  Abstract

Shamis Y, Silva EA, Hewitt KJ, Brudno Y, Levenberg S, Mooney DJ, Garlick JA. 2013. Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo. PLoS One 8: e83755. Abstract

Evans-Johnson JA, Garlick JA, Johnson EJ, Wang XD, Oliver Chen CY. 2013. A pilot study of the photoprotective effect of almond phytochemicals in a 3D human skin equivalent. J Photochem Photobiol B. 126: 17-25. Abstract

Lucier RN, Etienne O, Ferreira S, Garlick JA, Kugel G, Egles C. 2013. Soft-tissue alterations following exposure to tooth-whitening agents. J Periodontol. 84: 513-519. Abstract

Bellas E, Seiberg M, Garlick J, Kaplan DL. 2012. In vitro 3D full-thickness skin-equivalent tissue model using silk and collagen biomaterials. Macromol Biosci. 12: 1627-1636. Abstract

Hewitt KJ, Garlick JA. 2012. Cellular reprogramming to reset epigenetic signatures. Mol Aspects Med. 34: 841-848. Abstract

Lucier R, Etienne O, Ferreira S, Garlick J, Kugel G, Egles C. 2012. Soft tissue alterations following exposure to tooth whitening agents. J Peridontol. 84: 513-519. Abstract