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Graduate School of Biomedical Sciences

Recent Publications from the Gaglia Lab

Levene RE, Shrestha SD, Gaglia MM. 2021. The influenza A virus host shutoff factor PA-X is rapidly turned over in a strain-specific manner. J Virol. 27:JVI.02312-20. doi: 10.1128/JVI.02312-20. Abstract

Rahim MMA, Parsons BD, Price EL, Slaine PD, Chilvers BL, Seaton GS, Wight A, Medina-Luna D, Dey S, Grandy SL, Anderson LE, Zamorano Cuervo N, Grandvaux N, Gaglia MM, Kelvin AA, Khaperskyy DA, McCormick C, Makrigiannis AP. 2020. Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins. J Virol. 94: e00165-20.. Abstract

Daly R, Khaperskyy DA, Gaglia MM. 2020. Fine-tuning a blunt tool: Regulation of viral host shutoff RNases. PLoS Pathog. 16: e:1008385. Abstract

Gaglia MM, Munger K. 2019. Editorial overview: Viruses and cancer. Curr Opin Virol. 39:iii-iv. doi: 10.1016/j.coviro.2019.09.002.. Abstract

Butnaru M, Gaglia MM. 2019. The Kaposi's sarcoma-associated herpesvirus protein ORF42 is required for efficient virion production and expression of viral proteins. Viruses 11: 711.doi: 10.3390/v11080711. Abstract

Gaucherand L, Porter BK, Levene RE, Price EL, Schmaling SK, Rycroft CH, Kevorkian Y, McCormick C, Khaperskyy DA, Gaglia MM. 2019. The Influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression. Cell Rep. 27: 776-792. Abstract

Gaglia MM, Munger K. 2018. More than just oncogenes: Mechanisms of tumorigenesis by human viruses. Curr Opin Virol. 32: 48-59. Abstract

Levene RE, Gaglia MM. 2018. Host shutoff in Influenza A virus: Many means to an end. Viruses 10(9). pii: E475. Abstract

Butnaru M, Gaglia MM. 2018. Transcriptional and post-transcriptional regulation of viral gene expression in the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus. Curr Clin Microbiol Rep. 5: 219-228. Abstract

Tabtieng T, Gaglia MM. 2018. Emerging pro-viral roles of caspases during lytic replication of gammaherpesviruses. J Virol. 92(19). pii: e01011-17. Abstract

Tabtieng T, Degterev A, Gaglia MM. 2018. Caspase-dependent suppression of type I interferon signaling promotes Kaposi's sarcoma-associated herpesvirus lytic replication. J Virol. 92(10). pii: e00078-18. Abstract

Khaperskyy DA, Schmaling S, Larkins-Ford J, McCormick C, Gaglia MM. 2016. Selective degradation of host RNA polymerase II transcripts by influenza A virus PA-X host shutoff protein. PLoS Pathog. 12: e1005427.  Abstract

Gaglia MM, Rycroft CH, Glaunsinger BA 2015. Transcriptome-wide cleavage site mapping on cellular mRNAs reveals features underlying sequence-specific cleavage by the viral ribonuclease SOX. PLoS Pathog. 11: e1005305.  Abstract

Gaglia MM*, Jeong DE*, Ryu EA, Lee D, Kenyon C, Lee SJ. 2012. Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genetics 8: e1003133. * Equal contribution  Abstract

Gaglia MM, Covarrubias S, Wong W, Glaunsinger BA. 2012. A common strategy for host RNA degradation by divergent viruses. J Virol. 86: 9527-9530. Abstract

Covarrubias S*, Gaglia MM* Kumar GR, Wong W, Jackson AO, Glaunsinger BA. 2011. Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1. PLoS Pathog. 7: e1002339. * Equal contribution Abstract

Yamawaki TM, Berman JR, Suchanek-Kavipurapu M, McCormick M, Gaglia MM, Lee SJ, Kenyon C. 2010. The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol. 8: e1000468. Abstract

Gaglia MM, Glaunsinger BA. 2013. Viruses and the cellular RNA decay machinery. Wiley Interdiscip Rev RNA. 1: 47-59. Abstract

Gaglia MM, Kenyon C. 2009. Stimulation of movement in a quiescent, hibernation-like form of Caenorhabditis elegans by dopamine signaling. J Neurosci. 29: 7302-7314. Abstract