The reprogramming of host gene expression is an aspect of the interaction between viruses and infected cells that can be crucial for the success of the viral infection. We are interested in uncovering mechanisms viruses use to control host gene expression through the exploitation of cellular pathways. We use a combination of high-throughput transcriptional analysis and classical approaches to tackle these questions. Our studies focus on an AIDS-related pathogen, Kaposi’s sarcoma-associated herpesvirus (KSHV), which causes Kaposi’s sarcoma and aggressive lymphomas. Kaposi’s sarcoma remains the major cause of cancer-related death in parts of Africa. The function of many of ~90 genes of KSHV is unknown, but we have identified new roles for several of them in the control of gene expression. Understanding the biology of KSHV and other related herpesviruses will help in the design new therapeutic strategies and will also give us additional information on the normal working of cells.