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Graduate School of Biomedical Sciences

Recent Publications from the Forgac Lab

Collins MP, Forgac M. 2020. Regulation and function of V-ATPases in physiology and disease. Biochim Biophys Acta Biomembr. 15:183341. doi: 10.1016/j.bbamem.2020.183341. Abstract

Collins MP, Stransky LA, Forgac M. 2020. AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells. J Biol Chem. pii: jbc.RA120.013223. doi: 10.1074/jbc.RA120.013223. Abstract

McGuire CM, Collins MP, Sun-Wada G, Wada Y, Forgac M. 2019. Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells. J Biol Chem. 294: 11248-11258.  Abstract

Forgac, M. 2018. A new twist to V-ATPases and cancer. Oncotarget 9: 31793-31794.  Abstract

Collins MP, Forgac M. 2018. Regulation of V-ATPase assembly in nutrient sensing and function of V-ATPases in breast cancer metastasis. Front Physiol. 9:902.  Abstract

McGuire CM, Forgac M. 2018. Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling. J Biol. Chem. 293: 9113-9123.  Abstract

McGuire C, Stransky L, Cotter K, Forgac M. 2017. Regulation of V-ATPase activity. Front Biosci. 22:609-622.  Abstract

Cotter K, Liberman R, Sun-Wada G, Wada Y, Sgroi D, Naber S, Brown D, Breton S, Forgac M. 2016. The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer. Oncotarget 7: 46142-46157.   Abstract

Stransky L, Cotter K, Forgac M. 2016. The Function of V-ATPases in cancer. Physiol Rev. 96: 1071-1091.  Abstract

McGuire C, Cotter K, Stransky L, Forgac M. 2016. Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness. Biochim Biophys Acta 1857: 1213-1218.  Abstract

Cotter K, Stransky L, McGuire C, Forgac M. 2015. Recent insights into the structure, regulation, and function of the V-ATPases. Trends Biochem Sci. 40: 611-622.   Abstract

Stransky LA, Forgac M. 2015. Amino acid availability modulates vacuolar H+-ATPase assembly. J Biol. Chem. 290: 27360-27369.   Abstract

Cotter K, Capecci J, Sennoune S, Huss M, Maier M, Martinez-Zaguilan R, Forgac M. 2014. Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells. J Biol Chem. 290: 3680-3692. Abstract

Liberman R, Bond S, Shainheit MG, Stadecker MJ, Forgac M. 2014. Regulated assembly of the V-ATPase is increased during cluster disruption-induced maturation of dendritic cells through a PI-3 Kinase/mTOR-dependent pathway. J Biol Chem. 289: 1355-1362. Abstract

Capecci J, Forgac M. 2013. J Biol Chem. Function of V-ATPase a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells. 288: 32731-32741. Abstract

Liberman R, Cotter K, Baleja JD, Forgac M. 2013. Structural analysis of the N-terminal domain of subunit a of the yeast vacuolar ATPase (V-ATPase) using accessibility of single cysteine substitutions to chemical modification. J Biol Chem. 288: 22798-22808. Abstract

Toei M, Toei S, Forgac M.  2011. Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase. J Biol Chem. 286: 35176-35186. Abstract