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Graduate School of Biomedical Sciences

Recent Publications from the Feig Lab

Dickson D, Stohn P, Rodriguez LS, Hernandez A, Harrington A, Liaw L, Feig LA. 2020. Involvement of early embryonic miR-409-3p in the establishment of anxiety levels in female mice. Dev Neurobiol. doi: 10.1002/dneu.22756. Abstract

Jin SX, Dickson D, Maguire J, Feig LA. 2020. Ras-GRF1 in CRF cells controls the early adolescent female response to repeated stress. J Endocrinol. pii: JOE-19-0375.R2. doi: 10.1530/JOE-19-0375. Abstract

Dickson DA, Paulus JK, Mensah V, Lem J, Saavedra-Rodriguez L, Gentry A, Pagidas K, Feig LA. 2018. Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress. Transl Psychiatry 8: 101. Abstract

Wong R, Feig LA. 2016. Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras. Biochem Biophys Res Commun. Epub ahead of print.  Abstract

Uzturk BG, Jin SX, Rubin B, Bartolome C, Feig LA. 2015. Ras-GRF1 regulates the HPA axis specifically in early-adolescent female mice. J Endocrinol. 227: 1-12.  Abstract

Darcy MJ, Jin SX, Feig LA. 2014. R-Ras contributes to LTP and contextual discrimination. Neuroscience 277: 334-342. Abstract

Darcy MJ, Trouche S, Jin SX, Feig LA. 2014. Ras-GRF2 mediates LTP, survival and response to an enriched environment of newborn neurons in the hippocampus. Hippocampus 24: 1317-1329. Abstract

Jin SX, Bartolome C, Arai JA, Hoffman L, Uzturk BG, Kumar-Singh R, Waxham MN, Feig LA. 2014. Domain contributions to signaling specificity differences between Ras-Guanine Nucleotide Releasing Factor (Ras-GRF)1 and Ras-GRF2. J Biol Chem. 289: 16551-16664. Abstract

Darcy MJ, Trouche S, Jin SX, Feig LA. 2013. Age-dependent role for ras-GRF1 in the late stages of adult neurogenesis in the dentate gyrus. Hippocampus 24: 315-325. Abstract

Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA. 2013. Acquisition of contextual discrimination involves the appearance of a Ras-GRF1/p38 map kinase-mediated signaling pathway that promotes LTP. J Biol Chem. 288: 21703-21713. Abstract

Saavedra-Rodríguez L, Feig LA. 2013. Chronic social instability induces anxiety and defective social interactions across generations. Biol Psychiatry 73: 44-53. Abstract

Feig, LA. 2011. Regulation of neuronal function by Ras-GRF exchange factors. Genes Cancer 2: 306-319. Abstract

Alt-Holland A, Sowalsky AG, Szwec-Levin Y, Shamis Y, Hatch H, Feig LA, Garlick JA. 2011. Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src. J Invest Dermatol. 131: 2306-2315. Abstract

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA. 2011. RalA function in dermal fibroblasts is required for the progression of squamous cell carcinoma of the skin. Cancer Res. 71: 758-767.  Abstract

Arai JA, Feig LA. 2011. Long-lasting and transgenerational effects of an environmental enrichment on memory formation. Brain Res Bull. 85: 30-35. Abstract