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Graduate School of Biomedical Sciences

Recent Publications from the Byrnes Lab

Toorie AM, Vassoler FM, Qu F, Slonim D, Schonhoff CM, Byrnes EM. 2022. Intergenerational effects of preconception opioids on glucose homeostasis and hepatic transcription in adult male rats. Sci Rep. Jan 31;12(1):1599. doi: 10.1038/s41598-022-05528-w. Abstract

Vassoler FM, Isgate SB, Budge KE, Byrnes EM. 2022. HPA axis dysfunction during morphine withdrawal in offspring of female rats exposed to opioids preconception. Neurosci Lett. Jan 24:136479. doi: 10.1016/j.neulet.2022.136479. Abstract

Vassoler FM, Byrnes EM. 2021. Transgenerational effects on anxiety-like behavior following adolescent morphine exposure in female rats. Behav Brain Res. Mar 14:113239. doi: 10.1016/j.bbr.2021.113239. Abstract

Wlodarczyk-Li SA, Vassoler FM, Byrnes EM, Schonhoff CM. 2020. Oxycodone decreases dendritic complexity in female but not male rat striatal neurons in vitro. Neurosci Lett. 722:134856. Abstract

Vassoler FM, Toorie AM, Teceno DN, Walia P, Moore DJ, Patton TD, Byrnes EM. 2020. Paternal morphine exposure induces bidirectional effects on cocaine versus opioid self-administration. Neuropharmacology 162: 107852. Abstract

Toorie AM, Vassoler FM, Qu F, Schonhoff CM, Bradburn S, Murgatroyd CA, Slonim DK, Byrnes EM. 2019. A history of opioid exposure in females increases the risk of metabolic disorders in their future male offspring. Addict Biol. 28:e12856. doi: 10.1111/adb.12856. Abstract

Vassoler FM, Toorie AM, Teceno DN, Walia P, Moore DJ, Patton TD, Byrnes EM. 2019. Paternal morphine exposure induces bidirectional effects on cocaine versus opioid self-administration. Neuropharmacology EPub ahead of print. Abstract

Vassoler FM, Toorie AM, Byrnes EM. 2019. Multi-, inter-, and transgenerational effects of drugs of abuse on behavior. Curr Top Behav Neurosci. 42: 247-258. Abstract

Lambert KG, Byrnes EM. 2019. Challenges to the parental brain: Neuroethological and translational considerations. Front Neuroendocrinol. 53: 100747. Abstract

Vassoler FM, Toorie AM, Byrnes EM. 2018. Increased cocaine reward in offspring of females exposed to morphine during adolescence. Psychopharmacology 236: 1261-1272. Abstract

Vassoler FM, Oranges ML, Toorie AM, Byrnes EM. 2018. Oxycodone self-administration during pregnancy disrupts the maternal-infant dyad and decreases midbrain OPRM1 expression during early postnatal development in rats. Pharmacol Biochem Behav. 173: 74-83. Abstract

Vassoler FM, Toorie AM, Byrnes EM. 2018. Transgenerational blunting of morphine-induced corticosterone secretion is associated with dysregulated gene expression in male offspring. Brain Res. 1679: 19-25. Abstract

Byrnes EM, Vassoler FM. 2017. Modeling prenatal opioid exposure in animals: Current findings and future directions. Front Neuroendocrinol. 51: 1-13. Abstract

Vassoler FM, Toorie AM, Byrnes EM. 2017. Transgenerational blunting of morphine-induced corticosterone secretion is associated with dysregulated gene expression in male offspring. Brain Res. 13(Pt A): 271-280. Abstract

Vassoler FM, Oliver DJ, Wyse C, Blau A, Shtutman M, Turner JR, Byrnes EM. 2016. Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure. Neuropharmacology 113(Pt A): 271-280. Abstract

Bless EP, Yang J, Acharya KD, Nettles SA, Vassoler FM, Byrnes EM, Tetel MJ. 2016. Adult neurogenesis in the female mouse hypothalamus: Estradiol and high-fat diet alter the generation of newborn neurons expressing estrogen receptor α. eNeuro. pii: ENEURO.0027-16. Abstract

Byrnes JJ, Gleason ED, Schoen MK, Lovelock DF, Carini LM, Byrnes EM, Bridges RS. 2016. Corrigendum to "Accelerated maternal responding following intra-VTA pertussis toxin treatment." Behav Brain Res. 303: 238. Abstract

Bodi CM, Vassoler FM, Byrnes EM. 2016. Adolescent experience affects postnatal ultrasonic vocalizations and gene expression in future offspring. Dev Psychobiol. 58: 714-723. Abstract

Vassoler FM, Wright SJ, Byrnes EM. 2015. Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring. Neuropharmacology. 103: 112-121. Abstract

Meadows KL, Byrnes EM. 2015. Sex- and age-specific differences in relaxin family peptide receptor expression within the hippocampus and amygdala in rats. Neuroscience 284: 337-348. Abstract

Ravenelle R, Santolucito HB, Byrnes EM, Byrnes JJ, Donaldson ST. 2014. Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in trait anxiety male rats. Neuroscience 270: 76-87. Abstract

Vassoler FM, Johnson-Collins NL, Carini LM, Byrnes EM. 2014. Next generation effects of female adolescent morphine exposure: sex-specific alterations in response to acute morphine emerge before puberty. Behav Pharmacol. 25: 173-181. Abstract

Byrnes EM, Casey K, Carini LM, Bridges RS. 2013. Reproductive experience alters neural and behavioral responses to acute oestrogen receptor alpha activation. J Neuroendocrinol. 25: 1280-1289. Abstract

Vassoler FM, Johnson NL, Byrnes EM. 2013. Female adolescent exposure to cannabinoids causes transgenerational effects on morphine sensitization in female offspring in the absence of in utero exposure. J Psychopharmacol. 27: 1015-1022. Abstract

Ravenelle R, Byrnes EM, Byrnes JJ, McInnis C, Park JH, Donaldson ST. 2013. Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats. Brain Behav Res 252: 47-52. Abstract

Byrnes JJ, Johnson NL, Carini LM, Byrnes EM. 2013. Multigenerational effects of adolescent morphine exposure on dopamine D2 receptor function. Psychopharmacology (Berl). 227: 263-272. Abstract

Byrnes JJ, Johnson NL, Schenk ME, Byrnes EM. 2012. Cannabinoid exposure in adolescent female rats induces transgenerational effects on morphine conditioned place preference in male offspring. J Psychopharmacol. 26: 1348-1354. Abstract

Byrnes EM, Casey K, Bridges RS. 2012. Reproductive experience modifies the effects of estrogen receptor alpha activity on anxiety-like behavior and corticotropin releasing hormone mRNA expression. Horm Behav. 61: 44-49. Abstract