Our lab uses preclinical modeling of neurological disorders to identify epigenetic modifications impacting both symptom severity and long-term outcomes. We are particularly interested in effects that are age- and/or sex-specific as well as effects that can be passed on to future generations (i.e. transgenerational epigenetic effects). Much of our work focuses on substance use disorders with a primary focus on opioids. Other more recent areas of interest include studies examining sex-specific neural modifications following ischemic stroke with a focus on changes that may play a role in the development of post-stroke depression.