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Graduate School of Biomedical Sciences

Stephen Bunnell

Associate Professor of Immunology
Stephen Bunnell

Stephen Bunnell

Associate Professor of Immunology

Office phone: 617-636-2174
Lab phone: 617-636-2779
Campus: Boston
Office: Jaharis 523B
Jaharis 524
BA, Biological Sciences, Cornell University
PhD, Biology, Harvard University
Postdoctoral Training, National Institutes of Health, Bethesda
Research synopsis: 

We are interested in the signaling complexes that control T cell differentiation and activation. Using advanced imaging techniques we examine the assembly and localization of these complexes in living T cells. The composition of these structures varies dynamically in a fashion that reflects the physiological constraints on T cell activation. We have shown that these structures cannot persist in the absence of any of several critical proteins. These proteins are therefore likely to form a cooperatively assembled core complex upon which complete signaling complexes are built. Finally, we have found that these complexes change in localization over time. We are currently defining the components of the core complex and are testing how changes in localization affect the generation of signals uniquely required for T cell activation.

Lab members: