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Graduate School of Biomedical Sciences

Rachel Buchsbaum

Jane F Desforges MD Chair of Hematology & Oncology
Rachel Buchsbaum

Rachel Buchsbaum

Jane F Desforges MD Chair of Hematology & Oncology

Office phone: 617-636-5147
Lab phone: 617-636-9554
Campus: Boston
Office: South 7
Laboratory: 
Tupper 6
Education: 
AB, Chemistry & Physics, Harvard University
MD, Cornell University Medical College
Postdoctoral Training, Tufts University School of Medicine
Research synopsis: 

My laboratory focuses on studying signal transduction pathways underlying cancer cell growth and metastasis. In particular, we are interested in pathways involving the Rac protein, a member of the Ras superfamily that is a central player in multiple signaling pathways affecting malignant cell behavior. We have found that Rac signaling can be directed through a network of distinct pathways, involving cell survival and apoptosis, cell cycling and growth, and migration and invasion, by a major regulator protein, Tiam1. A major interest is the regulation of this Tiam1/Rac signaling network in normal and malignant cells. We are also exploring the role of this network in governing interactions between tumor cells and their microenvironment.

Lab members: