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Graduate School of Biomedical Sciences

Recent Publications from the Bohm Lab

Meinke G, Dalda N, Brigham BS, Bohm A. 2021. Synthesis of libraries and multi-site mutagenesis using a PCR-derived, dU-containing template. Synth Biol. 6(1):ysaa030. doi: 10.1093/synbio/ysaa030.  Abstract

Bohm A. 2019. AMi: a GUI-based, open-source system for imaging samples in multi-well plates. Acta Crystallogr F Struct Biol Commun. 75: 531-536.  Abstract

Bohm A. 2018. An inexpensive system for imaging the contents of multi-well plates. Acta Crystallogr F Struct Biol Commun. 74: 797-802.  Abstract

Bogdanove AJ, Bohm A, Miller JC, Morgan RD, Stoddard BL. 2018. Engineering altered protein-DNA recognition specificity. Nucleic Acids Res. 46: 4845-4871.  Abstract

Takemoto Y, Slough DP, Meinke G, Katnik C, Graziano ZA, Chidipi B, Reiser M, Alhadidy MM, Ramirez R, Salvador-Montañés O, Ennis S, Guerrero-Serna G, Haburcak M, Diehl C, Cuevas J, Jalife J, Bohm A, Lin YS, Noujaim SF. 2017. Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule. FASEB J. 32: 1778-1793.   Abstract

Meinke G, Karpinski J, Buchholz F, Bohm A. 2017. Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA. Nucleic Acids Res. 45: 9726-9740.   Abstract

Schiemer J, Bohm A, Lin L, Merrill-Skoloff G, Flaumenhaft R, Huang JS, Le Breton GC, Chishti AH. 2016. Gα13 switch region 2 relieves talin autoinhibition to activate IαIbβ3 integrin. J Biol Chem. 229: 26598-26612.  Abstract

Shearer AM, Rana R, Austin K, Baleja JD, Nguyen N, Bohm A, Covic L, Kuliopulos A. 2016. Targeting liver fibrosis with a cell-penetrating PAR2 pepducin. J Biol Chem. 291: 23188-23198. Abstract

Grubman SA, Shin J, Phelan PJ, Gong A, Can H, Dilworth R, Kini SK, Gagnon D, Archambault J, Meinke G, Bohm A, Jefferson DM, Bullock PA. 2016. Isolation of a monoclonal antibody that recognizes the origin binding domain of JCV, but not SV40, large T-antigen. Virology. 497: 92-101. Abstract

Meinke G, Bohm A, Hauber J, Pisabarro MT, Buchholz F. 2016. Cre recombinase and other tyrosine recombinases. Chem Rev. 116: 12785-12820. Abstract

Meinke G, Phelan PJ, Shin J, Gagnon D, Archambault J, Bohm A, Bullock PA. 2016. Structural based analyses of the JC Virus T-antigen F258L mutant provides evidence for DNA dependent conformational changes in the C-termini of polyomavirus origin binding domains. PLoS Pathog. 12: e1005362.  Abstract

Zhang P, Leger AJ, Baleja JD, Rana R, Corlin T, Nguyen N, Koukos G, Bohm A, Covic L, Kuliopulos A. 2015. Allosteric activation of a G protein coupled receptor with cell-penetrating receptor mimetics. J Biol Chem. 290: 15785-15798. Abstract

Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. 2014. N-Glycosylation regulates ADAM8 processing and activation. J Biol Chem. 289: 33676-33688. Abstract

Harrison C, Jiang T, Banerjee P, Meinke G, D'Abramo CM, Schaffhausen B, Bohm A. 2013. Polyomavirus large T-antigen binds symmetrical repeats at the viral origin in an asymmetrical manner. J Virol. 87: 13751-13759. Abstract

Foley CJ, Fanjul-Fernández M, Bohm A, Nguyen N, Agarwal A, Austin K, Koukos G, Covic L, López-Otín C, Kuliopulos A. 2013. Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. Oncogenesis 33: 2264-2272. Abstract

Zhang P, Gruber A, Kasuda S, Kimmelstiel C, O'Callaghan K, Cox DH, Bohm A, Baleja JD, Covic L, Kuliopulos A. 2012. Suppression of arterial thrombosis without affecting hemostatic parameters with a cell-penetrating PAR1 pepducin. Circulation 126: 83091. Abstract

Ghazy MA, Gordon JM, Lee SD, Singh BN, Bohm A, Hampsey M, Moore C. 2012. The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site. Nucleic Acids Res. 40: 1214-1225. Abstract

Gordon JM, Shikov S, Kuehner JN, Liriano M, Lee E, Stafford W, Poulsen MB, Harrison C, Moore C, Bohm A. 2011. Reconstitution of CF IA from overexpressed subunits reveals stoichiometry and provides insights into molecular topology. Biochemistry 50: 10203-10214. Abstract

Sevigny LM, Zhang P, Bohm A, Lazarides K, Perides G, Covic L, Kuliopulos A. 2011. Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins. Proc Natl Acad Sci USA 108: 8491-8496. Abstract

Ezeokonkwo C, Zhelkovsky A, Lee R, Bohm A, Moore CL. 2011. A flexible linker region in Fip1 is needed for efficient mRNA polyadenylation. RNA 17: 652-664. Abstract

Harrison CJ, Meinke G, Kwun HJ, Rogalin H, Phelan PJ, Bullock PA, Chang Y, Moore PS, Bohm A. 2011. Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J Mol Biol. 409: 529-542. Abstract

Meinke G, Phelan PJ, Fradet-Turcotte A, Bohm A, Archambault J, Bullock PA. 2011. Structure-based analysis of the interaction between the simian virus 40 T-antigen origin binding domain and single-stranded DNA. J Virol. 85: 818-827. Abstract

Bose K, Meinke G, Bohm A, Baleja JD. 2011. Design and characterization of an enhanced repressor of human papillomavirus E2 protein. FASEB J. 25: 2354-2361.