I no longer accept GSBS students for rotations or thesis research but remain active in program activities.
My research focuses on reactive oxygen and nitrogen species generated during cellular metabolism and by certain environmental factors, including lifestyle, appear to play a critical role in the aging process. High dietary intakes of antioxidant vitamins and phytochemicals are associated with better maintenance of physiologic function and a lower prevalence of many degenerative conditions in older adults. Understanding how antioxidants, especially the carotenoids and polyphenols like the flavonoids, reduce oxidative stress and inflammation to impact the pathogenesis of chronic disease presents opportunities for health promotion and alternative therapeutic modalities for an aging population. We conduct studies of the multifunctional role of antioxidants, particularly the flavonoids and their synergy with other nutrients, on changes in oxidative stress, inflammation, and glucoregulation during aging. This work is conducted in vitro, in animal models, and in healthy and other human populations to elucidate antioxidant requirements for optimal health.