Student Publications

Publication in peer-reviewed journals is a very important part of graduate training. Recent publications by our students are listed below. The names of student authors are in bold font and their graduate program is listed.

2020

Collins MP, Stransky LA, Forgac M. 2020. AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells. J Biol Chem. pii: jbc.RA120.013223. doi: 10.1074/jbc.RA120.013223. Laura Stransky - CMP) Abstract

Krolewski RC, Lin B, Stampfer S, Packard A, Schwob JE. 2020. A group of olfactory receptor alleles that encode full length proteins are down-regulated as olfactory sensory neurons mature. Sci Rep. 10(1):1781. doi: 10.1038/s41598-020-58779-w. (Sam Stampfer - Biochemistry) Abstract

Li S, Goncalves KA, Lyu B, Yuan L, Hu GF. 2020. Chemosensitization of prostate cancer stem cells in mice by angiogenin and plexin-B2 inhibitors. Commun Biol. 3(1):26. doi: 10.1038/s42003-020-0750-6. (Kevin Goncalves - CMP) Abstract

Metrick CM, Koenigsberg AL, Heldwein EE. 2020. Conserved outer tegument component UL11 from herpes simplex virus 1 is an intrinsically disordered, RNA-binding protein. mBio. 11: pii: e00810-20. doi: 10.1128/mBio.00810-20. (Claire Metrick - Biochemistry) Abstract

Sharma S, Munger K. 2020. Expression of the long noncoding RNA DINO in human papillomavirus-positive cervical cancer cells reactivates the dormant TP53 tumor suppressor through ATM/CHK2 signaling. mBio. 11(3). pii: e01190-20. doi: 10.1128/mBio.01190-20. (Surendra Sharma - Biochemistry) Abstract

Sharma S, Munger K. 2020. The role of long noncoding RNAs in human papillomavirus-associated pathogenesis. Pathogens. 9(4). pii: E289. doi: 10.3390/pathogens9040289. (Surendra Sharma - Biochemistry) Abstract

Sharma S, Munger K. 2020. KDM6A mediated expression of the long noncoding RNA DINO causes TP53 tumor suppressor stabilization in Human Papillomavirus type 16 E7 expressing cells. J Virol. pii: JVI.02178-19. doi: 10.1128/JVI.02178-19. (Surendra Sharma - Biochemistry) Abstract

Yoon JK, Holloway JR, Wells DW, Kaku M, Jetton D, Brown R, Coffin JM. 2020. HIV proviral DNA integration can drive T cell growth ex vivo. Proc Natl Acad Sci USA 117: 32880-32882. (Joe Holloway - PPET) Abstract

2019

Almukadi H, Schwake C, Kaiser M, Mayer G, Schiemer J, Baldwin M, Hegde S, Lu Y, Hanada T, Chishti AH. 2019. Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid-rich protein. Blood 133: 470-480. (Haifa Almukadi - PPET; James Schiemer, Michael Baldwin - CMP; Shreeya Hegde - PDD) Abstract

Bawazeer MA, Theoharides TC. 2019. IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin. Eur J Pharmacol. 26:172760. doi: 10.1016/j.ejphar.2019.172760. (Mona Bawazeer - PPET) Abstract

Butnaru M, Gaglia MM. 2019. The Kaposi's sarcoma-associated herpesvirus protein ORF42 is required for efficient virion production and expression of viral proteins. Viruses 11(8). pii: E711. (Matt Butnaru - Biochemistry) Abstract

Holloway JR, Williams ZH, Freeman MM, Bulow U, Coffin JM. 2019. Gorillas have been infected with the HERV-K (HML-2) endogenous retrovirus much more recently than humans and chimpanzees. Proc Natl Acad Sci USA. 116: 1337-1346. (Joseph Holloway - PPET, Michael Freeman - Biochemistry) Abstract

Hwang SS, Chan H, Sorci M, Van Deventer J, Wittrup D, Belfort G, Walt D. 2019. Detection of amyloid β oligomers toward early diagnosis of Alzheimer's disease. Anal Biochem. 566: 40-45. (Sarah Hwang - Biochemistry) Abstract

Ledoux T, Aridgides D, Salvador R, Ngwenyama N, Panagiotidou S, Alcaide P, Blanton R, Perrin MA. 2019. Trypanosoma cruzi neurotrophic factor facilitates cardiac repair in a mouse model of chronic Chagas disease. J Pharmacol Exp Ther. 368: 11-20. (Tamar Ledoux & Smaro Panagiotidou - PPET Abstract

McGuire CM, Collins MP, Sun-Wada G, Wada Y, Forgac M. 2019. Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells. J Biol Chem. Epub ahead of print. (Christina McGuire - Biochemistry) Abstract

Michael ES, Covic L, Kuliopulos A. 2019. TAAR1 promotes anti-diabetic signaling in insulin-secreting cells. J Biol Chem. 294: 4401-4411. (Emily Michael - Biochemistry) Abstract

Mills J, Hanada T, Hase Y, Liscum L, Chishti AH. 2019. LDL receptor related protein 1 requires the I₃ domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B. Biochim Biophys Acta Mol Cell Res. 2:118552. doi: 10.1016/j.bbamcr.2019.118552. (Joslyn Mills - CMP) Abstract

Panaro BL, Coppage AL, Beaudry JL, Varin EM, Kaur K, Lai JH, Wu W, Liu Y, Bachovchin WW, Drucker DJ. 2019. Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice. Mol Metabo. 19: 65-74. (Andrew Coppage - Biochemistry) Abstract

Rana R, Shearer AM, Fletcher EK, Nguyen N, Guha S, Cox DH, Abdelmalek M, Wang Y, Baleja JD, Covic L, Kuliopulos A. 2019. PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease. Mol Metab. 29:99-113. (Andrew Shearer - Biochemistry) Abstract

Schwake C, Baldwin MR, Bachovchin W, Hegde S, Schiemer J, Okure C, Levin AE, Vannier E, Hanada T, Chishti AH. 2019. HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes. Biochem Biophys Res Commun. Epub ahead of print. (Michael Baldwin & James Schiemer - CMP) Abstract

Theoharides TC, Tsilioni I, Bawazeer M. 2019. Mast cells, neuroinflammation and pain in fibromyalgia syndrome. Front Cell Neurosci. 13:353. doi: 10.3389/fncel.2019.00353. (Mona Bawazeer - PPET) Abstract

White EM, Stampfer SD, Heldwein EE. 2019. Expression, purification, and crystallization of HSV-1 glycoproteins for structure determination. Methods Mol Biol. 2020;2060:377-393. doi: 10.1007/978-1-4939-9814-2_23. (Sam Stampfer - Biochemistry) Abstract

2018

Butnaru M, Gaglia MM. 2018. Transcriptional and post-transcriptional regulation of viral gene expression in the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus. Curr Clin Microbiol Rep. 5: 219-228. (Matthew Butnaru - Biochemistry) Abstract

Fiaturi N, Russo JW, Nielsen HC, Castellot JJ Jr. 2017. CCN5 in alveolar epithelial proliferation and differentiation during neonatal lung oxygen injury. J Cell Commun Signal. 12: 217-229. (Najla Fiaturi - PPET) Abstract

Gross AR, Theoharides TC. 2018. Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33. Biofactors Eupb ahead of print. (Amanda Gross - PPET) Abstract

Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A. 2018. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 9: 3116. (Bethany Delcuze - CMP) Abstract

McGuire CM, Forgac M. 2018. Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling. J Biol. Chem. 293: 9113-9123. (Christina McGuire - Biochemistry) Abstract

Sharma S, Munger K. 2018. Expression of the cervical carcinoma expressed PCNA regulatory (CCEPR) long noncoding RNA is driven by the human papillomavirus E6 protein and modulates cell proliferation independent of PCNA. Virology 518: 8-13. (Surendra Sharma - Biochemistry) Abstract

Sjoblom NM, Kelsey MMG, Scheck R. 2018. A systematic study of selective protein glycation. Angew Chem Int Ed Engl. 57: 16077-16082. (Nicole Sjoblom – Biochemistry) Abstract

Tabtieng T, Degterev A, Gaglia MM. 2018. Caspase-dependent suppression of type I interferon signaling promotes Kaposi's sarcoma-associated herpesvirus lytic replication. J Virol. 92: e00078-18. (Tate Tabtieng - Biochemistry) Abstract

Tabtieng T, Gaglia MM. 2018. Emerging pro-viral roles of caspases during lytic replication of gammaherpesviruses. J Virol. 92: e01011-01017. Abstract

Taracanova A, Tsilioni I, Conti P, Norwitz ER, Leeman SE, Theoharides TC. 2018. Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin. Proc Natl Acad Sci USA. 115: E9381-E9390. Abstract

2017

Cao L, Greenblatt DJ, Kwara A. 2017. Inhibitory effects of selected antituberculosis drugs on common human hepatic cytochrome P450 and UDP-glucuronosyltransferase enzymes. Drug Metab Dispos. 45: 1035-1043. (Lei Cao - PPET) Abstract

Cao L, Kwara A, Greenblatt DJ. 2017. Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol.69: 1762-1772. (Lei Cao - PPET) Abstract

Du C, Collins W, Cantley W, Sood D, Kaplan DL. 2017. Tutorials for electrophysiological recordings in tissue engineering. ACS Biomater Sci Eng. 3: 2235-2246. (Will Collins - PPET) Abstract

Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. 2016. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe 21: 169-181. (Nicole Sjoblom - Biochemistry) Abstract

Kulkarni S, Goel S, Sengupta S, Cochran BH. 2017. A large-scale RNAi screen identifies SGK1 as a key survival kinase for GBM stem cells. Mol Cancer Res. 16: 101-114. (Shreya Kulkarni, Senjuti Sengputa - CMP) Abstract

McGuire C, Stransky L, Cotter K, Forgac M. 2017. Regulation of V-ATPase activity. Front Biosci. 22:609-622. (Christina McGuire - Biochemistry; Laura Stransky, Kristina Cotter - CMP) Abstract

Nwankwo JO, Gremmel T, Gerrits AJ, Mithila FJ, Warburton RR, Hill NS, Lu Y, Richey LJ, Jakubowski JA, Frelinger AL 3rd, Chishti AH. 2017. Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease. Thromb Res. 160: 58-65. (Jennifer Nwankwo - PPET) Abstract

Patel AB, Tsilioni I, Weng Z, Theoharides TC. 2017. TNF stimulates IL-6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin. Exp Dermatol. 27: 135-143. (Arti Patel - Biochemistry) Abstract

Patel AB, Theoharides TC. 2017. Methoxyluteolin inhibits neuropeptide-stimulated proinflammatory mediator release via mTOR activation from human mast cells. J Pharmacol Exp Ther. 361: 462-471. (Arti Patel - Biochemistry) Abstract

Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A. 2017. Kinase activities of RIPK1 and RIPK3 can direct IFN-β synthesis induced by lipopolysaccharide. J Immunol. 198: 4435-4447. (Malek Najjar - PPET) Abstract

Sherry-Lynes MM, Sengupta S, Kulkarni S, Cochran BH. 2017. Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3. PLoS One 12: e0174775. (Maureen Sherry-Lynes, Senjuti Sengupta, Shreya Kulkarni - CMP) Abstract

Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, Leeman SE, Theoharides TC. 2017. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci USA 14: E4002-E4009. (Alexandra Taracanova - PPET) Abstract

Yu W, Goncalves KA, Li S, Kishikawa H, Sun G, Yang H, Vanli N, Wu Y, Jiang Y, Hu MG, Friedel RH, Hu GF. 2017. Plexin-B2 mediates physiologic and pathologic functions of angiogenin. Cell 171: 849-864. (Kevin Goncalves - CMP; Nil Vanli - Biochemistry) Abstract

2016

Coppage AL, Heard KR, DiMare MT, Liu Y, Wu W, Lai JH, Bachovchin WW. 2016. Human FGF-21 Is a substrate of fibroblast activation protein. PLoS One 11(3): e0151269. (Andrew Coppage - Biochemistry) Abstract

Cotter K, Liberman R, Sun-Wada G, Wada Y, Sgroi D, Naber S, Brown D, Breton S, Forgac M. 2016. The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer. Oncotarget. 7(29): 46142-46157. (Kristina Cotter and Rachel Liberman - CMP) Abstract

Denis D, Rouleau C, Schaffhausen BS. 2016. A transformation-defective polyomavirus middle T antigen with a novel defect in PI3 kinase signaling. J Virol. 91(2). pii: e01774-16. (Deborah Denis and Cecile Rouleau - Biochemistry) Abstract

Goncalves KA, Silberstein L, Li S, Severe N, Hu MG, Yang H, Scadden DT, Hu GF. 2016. Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells. Cell 166(4): 894-906. (Kevin Goncalves - CMP) Abstract

Gu S, Chan WW, Mohi G, Rosenbaum J, Sayad A, Lu Z, Virtanen C, Li S, Neel BG, Van Etten RA. 2016. Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1. Blood 127(14): 1803-1813. (Wayne Chan - CMP) Abstract

Julian B, Gao K, Harwood BN, Beinborn M, Kopin AS. 2016. Mutation-induced functional alterations of CCR6. J Pharmacol Exp Ther. 360: 106-116. (Bina Julian - PPET) Abstract

Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. 2016. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe. 21(2): 169-181. (Nicole Sjoblom - Biochemistry) Abstract

Lu Y, Hanada T, Fujiwara Y, Nwankwo JO, Wieschhaus AJ, Hartwig J, Huang S, Han J, Chishti AH. 2016. Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood. 128: 93-103. (Jennifer Nwankwo - PPET) Abstract

Metrick CM, Heldwein EE. 2016. The novel structure and unexpected RNA-binding ability of the C-terminal domain of HSV-1 tegument protein UL21. J Virol. 90(12): 5759-5769. Abstract (Claire Metrick - Biochemistry)

McGuire C, Cotter K, Stransky L, Forgac M. 2016. Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness. Biochim Biophys Acta. 1857(8): 1213-1218. Abstract (Christina McGuire - Biochemistry; Kristina Cotter and Laura Stransky - CMP)

Najjar M*, Saleh D*, Zelic M, Nogusa S, Shah A, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen M, Pasparakis, Balachandran S, Kelliher M, Poltorak A, Degterev A. 2016. RIPK1 and RIPK3 kinases promote cell death-independent inflammation by TLR4-TRIF Immunity. 45: 46-59. * equal contribution. (Malek Najjar - PPET) Abstract

Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. 2016. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica. 101: e397-e400. (Jennifer Nwankwo - PPET) Abstract

Patel AB, Tsilioni I, Leeman SE, Theoharides TC. 2016. Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism. Proc Natl Acad Sci USA. pii: 201604992. (Arti Patel - Biochemistry) Abstract

Rogalin HB, Heldwein EE. 2016. Characterization of VSV pseudotypes bearing essential entry glycoproteins gB, gD, gH, and gL of Herpes Simplex virus Type 1. J Virol. 90(22): 10321-10328. (Henry Rogalin - Biochemistry) Abstract

Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. 2016. Transformation by Polyomavirus middle T antigen involve a unique bimodal interaction with the Hippo effector YAP. J Virol. 90: 7032-7045. (Cecile Rouleau - Biochemistry) Abstract

Shearer AM, Rana R, Austin K, Baleja JD, Nguyen N, Bohm A, Covic L, Kuliopulos A. 2016. Targeting liver fibrosis with a cell-penetrating PAR2 pepducin. J Biol Chem. 291: 23188-23198. (Andrew Shearer - Biochemistry) Abstract

Sheets AR, Demidova-Rice TN, Shi L, Ronfard V, Grover KV, Herman IM. 2016. Identification and characterization of novel matrix-derived bioactive peptides: A role for collagenase from Santyl® ointment in post-debridement wound healing? PLoS One 11: e0159598. (Anthony Sheets - CMP) Abstract

Sheets AR, Durham JT, Herman IM. 2016. Quantitative imaging-based examination of pericytes controlling endothelial growth dynamics and angiogenesis. Methods Mol Biol. 1430: 221-229. (Anthony Sheets - CMP) Abstract

Sheets AR, Massey CJ, Cronk SM, Iafrati MD, Herman IM. 2016. Matrix- and plasma-derived peptides promote tissue-specific injury responses and wound healing in diabetic swine. J Transl Med. 14(1): 197. Anthony Sheets - CMP) Abstract

Schiemer J, Bohm A, Lin L, Merrill-Skoloff G, Flaumenhaft R, Huang JS, Le Breton GC, Chishti AH. 2016. Gα13 switch region 2 relieves talin autoinhibition to activate IαIbβ3 integrin. J Biol Chem. 291(52): 26598-26612. (James Schiemer - CMP) Abstract

Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT. 2016. Cell Stem Cell. 19: 530-543. (Kevin Goncalves - CMP) Abstract

Stransky L, Cotter K, Forgac M. 2016. The Function of V-ATPases in cancer. Physiol Rev. 96(3): 1071-1091. (Laura Stransky and Kristina Cotter - CMP) Abstract

Szabo R, Lantsman T, Peters DE, Bugge TH. 2016. Delineation of proteolytic and non-proteolytic functions of membrane-anchored serine protease Prss8/prostasin. Development 143: 2818-2828. (Diane Peters - PPET) Abstract

Theoharides TC, Stewart JM, Taracanova A, Conti P, Zouboulis CC. 2016. Neuroendocrinology of the skin. Rev Endocr Meab Disorders. 17: 287-294. (Alexandra Taracanova - PPET)Abstract

Theoharides TC, Tsilioni I, Patel AB, Doyle R. 2016. Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders. Transl Psychiatry. 6: e844. (Arti Patel - Biochemistry) Abstract

Weng Z, Zhang B, Tsilioni I, Theoharides TC. 2016. Nanotube formation: A rapid form of "alarm signaling"? Clin Ther. 38: 1066-1072. (Katie Weng - PPET) Abstract

Yang E, Cisowski J, Nguyen N, O'Callaghan K, Xu J, Agarwal A, Kuliopulos A, Covic L. 2016. Dysregulated protease activated receptor 1 (PAR1) promotes metastatic phenotype in breast cancer through HMGA2. Oncogene 35: 1529-40. (Eric Yang - Biochemistry) Abstract

Wong DS, Jay DG. 2016. Emerging roles of extracellular Hsp90 in cancer. Adv Cancer Res. 129: 141-163. (Daniel Wong - CMP) Abstract

Wong R, Feig LA. 2016. Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras. Biochem Biophys Res Commun. 480(3): 468-473. (Richard Wong - Biochemistry) Abstract

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