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Immunology Student Publications

Publication in peer-reviewed journals is a very important part of graduate training. Publications by Immunology students over the past five years are listed below. The names of student authors are in bold font.


Anastasiou M, Newton GA, Kaur K, Carrillo-Salinas FJ, Smolgovsky SA, Bayer AL, Ilyukha V, Sharma S, Poltorak A, Luscinskas FW, Alcaide P. 2021. Endothelial STING controls T-cell transmigration in an IFN-I dependent manner. JCI Insight. 22:149346. doi: 10.1172/jci.insight.149346. Abstract

Bayer AL, Alcaide P. 2021. MyD88: At the heart of inflammatory signaling and cardiovascular disease. J Mol Cell Cardiol. Aug 6:S0022-2828(21)00154-1. doi: 10.1016/j.yjmcc.2021.08.001. Abstract

Eidell KP, Lovy A, Sylvain NR, Scangarello FA, Muendlein HI, ,Ophir MJ, Nguyen K, Seminario MC, Bunnell SC. 2021. LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors. J Cell Sci. 19:jcs.258602. doi: 10.1242/jcs.258602. Abstract

Larkins-Ford J, Greenstein T, Van N, Degefu YN, Olson MC, Sokolov A, Aldridge BB. 2021. Systematic measurement of combination-drug landscapes to predict in vivo treatment outcomes for tuberculosis. Cell Syst. Aug 21:S2405-4712(21)00292-1. doi: 10.1016/j.cels.2021.08.004. Abstract

Joma BH, Siwapornchai N, Vanguri VK, Shrestha A, Roggensack SE, Davidson BA, Tai AK, Hakansson AP, Meydani SN, Leong JM, Bou Ghanem EN. 2021. A murine model for enhancement of Streptococcus pneumoniae pathogenicity upon viral infection and advanced age. Infect Immun. 24:IAI.00471-20. doi: 10.1128/IAI.00471-20. Abstract

Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. 2021. ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1. Nat Commun. 12(1):86. doi: 10.1038/s41467-020-20357-z. Abstract

Ngwenyama N, Kirabo A, Aronovitz M, Velázquez F, Carrillo-Salinas F, Salvador AM, Nevers T, Amarnath V, Tai A, Blanton RM, Harrison DG, Alcaide P. 2021. Isolevuglandin-modified cardiac proteins drive CD4+ T cell activation in the heart and promote cardiac dysfunction. Circulation. doi: 10.1161/CIRCULATIONAHA.120.051889.  Abstract


Bhalchandra S, Lamisere H, Ward H. 2020. Intestinal organoid/enteroid-based models for Cryptosporidium. Curr Opin Microbiol. 58: 124-129. Abstract

Cameron J, Martino P, Nguyen L, Li X. 2020. Cutting Edge: CRISPR-based transcriptional regulators reveal transcription-dependent establishment of epigenetic memory of Foxp3 in regulatory T cells. J Immunol. 2:ji2000537. doi: 10.4049/jimmunol.2000537. Abstract

Carrillo-Salinas FJ, Anastasiou M, Ngwenyama N, Kaur K, Tai A, Smolgovsky SA, Jetton D, Aronovitz M, Alcaide P. 2020. Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner. Gut Microbes 12: 1-20. Abstract

de Lara LM, Parthasarathy RS, Rodriguez-Garcia M. 2021. Mucosal immunity and HIV acquisition in women. Curr Opin Physiol. 19: 32-38. Abstract

Fasciano AC, Mecsas J. 2020. Eat your Vitamin A: A role for retinoic acid in the development of M cells. Gastroenterology pii: S0016-5085(20)30652-1. doi: 10.1053/j.gastro.2020.05.029. Abstract

Fray MA, Charpentier JC, Sylvain NR, Seminario MC, Bunnell SC. 2020. Vav2 lacks calcium entry-promoting scaffolding functions unique to Vav1 and inhibits T cell activation via Cdc42. J Cell Sci. pii: jcs.238337. doi: 10.1242/jcs.238337. Abstract

Jamali A, Kenyon B, Ortiz G, Abou-Slaybi A, Sendra VG, Harris DL, Hamrah P. 2020. Plasmacytoid dendritic cells in the eye. Prog Retin Eye Res. 24:100877. doi: 10.1016/j.preteyeres.2020.100877. Abstract

Moir DT, Bowlin NO, Berube BJ, Yabut J, Mills DM, Nguyen GT, Aron ZD, Williams JD, Mecsas J, Hauser AR, Bowlin TL. 2020. A structure-function-inhibition analysis of the P. aeruginosa Type III secretion needle protein PscF. J Bacteriol. pii: JB.00055-20. doi: 10.1128/JB.00055-20. Abstract

Muendlein HI*, Sarhan J*, Liu BC, Connolly WM, Schworer SA, Smirnova I, Tang AY, Ilyukha V, Pietruska J, Tahmasebi S, Sonenberg N, Degterev A, Poltorak A. 2020. Constitutive interferon attenuates RIPK1/3-mediated cytokine translation. Cell Rep. 30: 699-713. * Equal contribution. Abstract

Muendlein HI, Jetton D, Connolly WM, Eidell KP, Magri Z, Smirnova I, Poltorak A. 2020. cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation. Science 367: 1379-1384. Abstract

Nguyen GT, Shaban L, Mack M, Swanson KD, Bunnell SC, Sykes DB, Mecsas J. 2020. SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. Elife pii: e56656. doi: 10.7554/eLife.56656. Abstract

Paczosa MK, Silver RJ, McCabe AL, Tai AK, McLeish CH, Lazinski DW, Mecsas J. 2020. Transposon mutagenesis screen of Klebsiella pneumoniae identifies multiple genes important for resisting antimicrobial activities of neutrophils in mice. Infect Immun. pii: IAI.00034-20. doi: 10.1128/IAI.00034-20. Abstract

Shaban L, Nguyen GT, Mecsas-Faxon BD, Swanson KD, Tan S, Mecsas J. 2020. Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection. PLoS Pathog. 16: e1008576. Abstract

Smolgovsky S, Ibeh U, Tamayo TP, Alcaide P. 2020.Adding insult to injury - Inflammation at the heart of cardiac fibrosis. Cell Signal.6:109828. doi: 10.1016/j.cellsig.2020.109828. Abstract

Yoon JK, Holloway JR, Wells DW, Kaku M, Jetton D, Brown R, Coffin JM. 2020. HIV proviral DNA integration can drive T cell growth ex vivo. Proc Natl Acad Sci USA 117: 32880-32882. Abstract


Bagley J, Williams L, Hyde M, Birriel CP, Iacomini J. 2019. Hyperlipidemia and allograft rejection. Curr Transpl Rep. 6: 90–98. 6: 90.

Cardenas D, Bhalchandra S, Lamisere H, Chen Y, Zeng XL, Ramani S, Karandikar UC, Kaplan DL, Estes MK, Ward HD. 2019. Two- and three-dimensional bioengineered human intestinal tissue models for Cryptosporidium. Methods Mol Biol. 2052:373-402. Abstract

Carrillo-Salinas FJ, Ngwenyama N, Anastasiou M, Kaur K, Alcaide P. 2019. Heart inflammation: immune cells roles and roads to the heart. Am J Pathol. Epub ahead of print. Abstract

Fasciano AC, Mecsas J, Isberg RR. 2019. New age strategies to reconstruct mucosal tissue colonization and growth in cell culture systems. Microbiol Spectr. 7. doi: 10.1128/microbiolspec.BAI-0013-2019. Abstract

Fasciano AC, Blutt SE, Estes MK, Mecsas J. 2019. Induced differentiation of M cell-like cells in human stem cell-derived ileal enteroid monolayers. J Vis Exp.(149). doi: 10.3791/59894. Abstract

Fasciano AC, Mecsas J, Isberg RR. 2019. New age strategies to reconstruct mucosal tissue colonization and growth in cell culture systems. Microbiol Spectr. 7. doi: 10.1128/microbiolspec.BAI-0013-2019. Abstract

Nguyen GT, McCabe AL, Fasciano AC, Mecsas J. 2019. Detection of cells translocated with Yersinia Yops in infected tissues using β-lactamase fusions. Methods Mol Biol. 2010: 117-139. Abstract

Ledoux T, Aridgides D, Salvador R, Ngwenyama N, Panagiotidou S, Alcaide P, Blanton R, Perrin MA. 2019. Trypanosoma cruzi neurotrophic factor facilitates cardiac repair in a mouse model of chronic Chagas disease. J Pharmacol Exp Ther. 368: 11-20. Abstract

Ngwenyama N, Salvador AM, Velázquez F, Nevers T, Levy A, Aronovitz MJ, Luster AD, Huggins GS, Alcaide P. 2019. CXCR3 regulates CD4+ T cell cardiotropism in pressure overload induced cardiac dysfunction. JCI Insight 4 (7) pii: 125527. doi: 10.1172/jci.insight.125527. Abstract

Sarhan J, Liu BC, Muendlein HI, Weindel CG, Smirnova I, Tang AY, Ilyukha V, Sorokin M, Buzdin A, Fitzgerald KA, Poltorak A. 2019. Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death Differ. 26: 332-347 Abstract

Silver RJ, Paczosa MK, McCabe AL, Balada-Llasat JM, Baleja JD, Mecsas J. 2019. Amino acid biosynthetic pathways are required for Klebsiella pneumoniae growth in immunocompromised lungs and are druggable targets during infection. Antimicrob Agents Chemother. Epub ahead of print. Abstract

Velázquez FE, Anastasiou M, Carrillo-Salinas FJ, Ngwenyama N, Salvador AM, Nevers T, Alcaide P. 2019. Sialomucin CD43 regulates Th17 cell ICAM-1 dependent adhesion, apical migration and transendothelial migration. Immunology 157: 52-69. Abstract


DeCicco RePass MA, Bhat N, Molinaro JH, Bunnell S, Cummings RD, Ward HD. 2018. Molecular cloning, expression, and characterization of UDP N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum. Mol Biochem Parasitol. 221: 56-65. Abstract

Kalantari P, Morales Y, Miller EA, Jaramillo LD, Ponichtera HE, Wuethrich MA, Cheong C, Seminario MC, Russo JM, Bunnell SC, Stadecker MJ. 2018. CD209a synergizes with Dectin-2 and mincle to drive severe Th17 cell-mediated schistosome egg-induced immunopathology. Cell Rep. 22: 1288-1300. Abstract

Lewis JB, Scangarello FA, Murphy JM, Eidell KP, Sodipo MO, Ophir MJ, Sargeant R, Seminario MC, Bunnell SC. 2018. ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters. J Cell Sci. 13(21) pii: jcs215517. doi: 10.1242/jcs.21551. Abstract

Liu BC, Sarhan J, Poltorak A. 2018. Host-intrinsic interferon status in infection and immunity. Trends Mol Med. 24: 658-668. Abstract

Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A. 2018. Constitutive interferon maintains GBP expression required for release of bacterial components upstream of pyroptosis and anti-DNA responses. Cell Rep. 24: 155-168. Abstract

Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A. 2018. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc Natl Acad Sci USA. 115: E10888-108987. Abstract

Shaban L, Chen Y, Fasciano AC, Lin Y, Kaplan DL, Kumamoto CA, Mecsas J. 2018. A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe 50: 85-92. Abstract


Bou Ghanem EN, Lee JN, Joma BH, Meydani SN, Leong JM, Panda A. 2017. The Alpha-tocopherol form of Vitamin E boosts elastase activity of human PMNs and their ability to kill Streptococcus pneumoniae. Front Cell Infect Microbiol. 7:161.  Abstract

DeCicco RePass MA, Chen Y, Lin Y, Zhou W, Kaplan DL, Ward HD. 2017. A novel bioengineered 3D human intestinal model for long-term infection of Cryptosporidium parvum. Infect Immun. 85: pii: e00731-16. Abstract

Larkin B, Ilyukha V, Sorokin M, Buzdin A, Vannier E, Poltorak A. 2017. Cutting Edge: Activation of STING in T cells induces Type I IFN responses and cell death. J Immunol. 199: 397-402. Abstract

Nevers T, Salvador AM, Velazquez F, Ngwenyama N, Carrillo-Salinas FJ, Aronovitz M, Blanton RM, Alcaide P. 2017. Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure. J Exp Med. 214: 3311-3329. Abstract

Nguyen GT, Green ER, Mecsas J. 2017. Neutrophils to the ROScue: Mechanisms of NADPH oxidase activation and bacterial resistance. Front Cell Infect Microbiol. 7:373. Abstract

Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A. 2017. Kinase activities of RIPK1 and RIPK3 can direct IFN-β synthesis induced by lipopolysaccharide. J Immunol. 198: 4435-3347.  Abstract

Vong M, Ludington JG, Ward HD, Nibert ML. 2017. Complete cryspovirus genome sequences from Cryptosporidium parvum isolate Iowa. Arch Virol. 162: 2875-2879. Abstract


Ludington JG, Ward HD. 2016. The Cryptosporidium parvum C-type lectin CpClec mediates infection of intestinal epithelial cells via interactions with sulfated proteoglycans. Infect Immun. 84: 1593-1602.  Abstract

Paczosa MK, Mecsas J. 2016. Klebsiella pneumoniae: Going on the offense with a strong defense. Microbiol Mol Biol Rev. 80: 629-661.  Abstract

Ram DR, Ilyukha V, Volkova T, Buzdin A, Tai A, Smirnova I, Poltorak A. 2016. Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo. Proc Natl Acad Sci USA 113: 1606-1611.  Abstract

Salvador AM, Nevers T, Velázquez F, Aronovitz M, Wang B, Abadía Molina A, Jaffe IZ, Karas RH, Blanton RM, Alcaide P. 2016. Intercellular adhesion molecule 1 regulates left ventricular leukocyte infiltration, cardiac remodeling, and function in pressure overload-induced heart failure. J Am Heart Assoc. pii: e003126.  Abstract

Sampson JF, Suryawanshi A, Chen WS, Rabinovich GA, Panjwani N. 2016. Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling. Immunol Cell Biol. 94: 213-219.   Abstract

Surpris G, Poltorak A. 2016. The expanding regulatory network of STING-mediated signaling.  Curr Opin Microbiol. 32: 144-150. Abstract

Surpris G, Chan J, Thompson M, Ilyukha V, Liu BC, Atianand M, Sharma S, Volkova T, Smirnova I, Fitzgerald KA, Poltorak A. 2016. Cutting Edge: Novel Tmem173 allele reveals importance of STING N terminus in trafficking and type I IFN production. J Immunol. 196: 547-552. Abstract

Thorley-Lawson D, Deitsch KW, Duca KA, Torgbor C. 2016. The link between Plasmodium falciparum malaria and dndemic Burkitt's Lymphoma-New insight into a 50-year-old enigma. PLoS Pathog. 12: e1005331.  Abstract

Velázquez F, Grodecki-Pena A, Knapp A, Salvador AM, Nevers T, Croce KJ, Alcaide P. 2016. CD43 functions as an E-selectin ligand for Th17 cells in vitro and is required for rolling on the vascular endothelium and Th17 cell recruitment during inflammation in vivo. J Immunol. 196: 1305-1316.  Abstract


Ludington JG, Ward HD. 2015. Systemic and mucosal immune responses to Cryptosporidium-vaccine development. Curr Topics Med Rep. 2: 171-180.  Abstract

McDonald G, Cabal N, Vannier A, Umiker B, Yin RH, Orjalo AV Jr, Johansson HE, Han JH, Imanishi-Kari T. 2015. Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked Toll-like receptor 8. Front Immunol. 6: 457. Abstract

Nevers T, Salvador AM, Grodecki-Pena A, Knapp A, Velazquez F, Aronovitz M, Kapur NK, Karas RH, Blanton RM, Alcaide P. 2015. Left ventricular T cell recruitment contributes to the pathogenesis of heart failure. Circ Heat Fail. 8: 776-787.  Abstract

Qiu J, Smith P, Leahy L, Thorley-Lawson DA. 2015. The Epstein-Barr virus encoded BART miRNAs potentiate tumor growth In vivo. PLoS Pathog. 11: e1004561. Abstract

Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. 2015. A single bacterial immune evasion strategy dismantles both MyD88 and TRIF signaling pathways downstream of TLR4. Cell Host Microbe 18: 682-693.   Abstract

Sampson JF, Hasegawa E, Mulki L, Suryawanshi A, Jiang S, Chen WS, Rabinovich GA, Connor KM, Panjwani N. 2015. Galectin-8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response. PLoS One 10: e130772.  Abstract

Smith PM, Sproule TJ, Philip VM, Roopenian DC, Stadecker MJ. 2015. Minor genomic differences between related B6 and B10 mice affect severity of schistosome infection by governing the mode of dendritic cell activation. Eur J Immunol. 45: 2312-2323. Abstract

Suryawanshi A, Cao Z, Sampson JF, Panjwani N. 2015. IL-17A-mediated protection against Acanthamoeba keratitis. J Immunol. 194: 650-663. Abstract