Genetics Student Publications
Publication in peer-reviewed journals is a very important part of graduate training. Publications by Genetics students over the past five years are listed below. The names of student authors are in bold font.
2021
Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. 2021. ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1. Nat Commun. 12(1):86. doi: 10.1038/s41467-020-20357-z. Abstract
Neil AJ, Hisey JA, Quasem I, McGinty RJ, Hitczenko M, Khristich AN, Mirkin SM. 2021. Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging. Proc Natl Acad Sci USA 118(5):e2013080118. doi: 10.1073/pnas.2013080118. Abstract
2020
Brown RE, Freudenreich CH. 2020. Structure-forming repeats and their impact on genome stability. Curr Opin Genet Dev. 67:41-51. Abstract
Jackson HM, Foley KE, O'Rourke R, Stearns TM, Fathalla D, Morgan BP, Howell GR. 2020. A novel mouse model expressing human forms for complement receptors CR1 and CR2. BMC Genet. 21: 101. doi: 10.1186/s12863-020-00893-9. Abstract
Lee SD, Liu HY, Graber JH, Heller-Trulli D, Kaczmarek Michaels K, Cerezo JF, Moore CL. 2020. Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation. RNA Biol. doi: 10.1080/15476286.2020.1724717. Abstract
Liu F, Yang L, Li Y, Junier A, Ma F, Chen J, Han H, Glass Z, Zhao X, Kumamoto CA, Sang H, Xu Q. 2020. In vitro and in vivo Study of Amphotericin B formulation with quaternized bioreducible lipidoids. ACS Biomater Sci Eng. 6: 1064-1073. doi: 10.1021/acsbiomaterials.9b01722. Abstract
Muendlein HI, Poltorak A. 2020. Flipping the switch from inflammation to cell death. Trends Immunol. pii: S1471-4906(20)30131-9. doi: 10.1016/j.it.2020.06.007. Abstract
Muendlein HI, Jetton D, Connolly WM, Eidell KP, Magri Z, Smirnova I, Poltorak A. 2020. cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation. Science 367: 1379-1384. Abstract
Muendlein HI*, Sarhan J*, Liu BC, Connolly WM, Schworer SA, Smirnova I, Tang AY, Ilyukha V, Pietruska J, Tahmasebi S, Sonenberg N, Degterev A, Poltorak A. 2020. Constitutive interferon attenuates RIPK1/3-mediated cytokine translation. Cell Rep. 30: 699-713. * Equal contribution. Abstract
Yoon JK, Holloway JR, Wells DW, Kaku M, Jetton D, Brown R, Coffin JM. 2020. HIV proviral DNA integration can drive T cell growth ex vivo. Proc Natl Acad Sci USA 117: 32880-32882. Abstract
2019
Alexander CK, Cronin KL, Silver M, Gardner HL, London C 2019. The addition of metronomic chemotherapy does not improve outcome for canine splenic haemangiosarcoma. J Small Anim Pract. 60: 32-37. Abstract
Barrett LE, Gardner HL, Barber LG, Sadowski A, London CA. 2019. Safety and toxicity of combined oclacitinib and carboplatin or doxorubicin in dogs with solid tumors: a pilot study. BMC Vet Res. 15: 291. Abstract
Bhattacharyya T, Walker M, Powers NR, Brunton C, Fine AD, Petkov PM, Handel MA. 2019. Prdm9 and meiotic cohesin proteins cooperatively promote DNA double-strand break formation in mammalian spermatocytes. Curr Biol. 29: 1002-1018. Abstract
Buchanan RA, Foley KE, Pepper KW, Reagan AM, Keezer KJ, Hewes AA, Diemler CA, Preuss C, Soto I, John SWM, Howell GR. 2019. Meox2 haploinsufficiency accelerates axonal degeneration in DBA/2J glaucoma. Invest Ophthalmol Vis Sci. 60: 3238-3296. Abstract
Christenson ET, Isaac DT, Yoshida K, Lipo E, Kim JS, Ghirlando R, Isberg RR, Banerjee A 2019. The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter. Proc Natl Acad Sci USA 116: 17775-17785. Abstract
Fine AD, Ball RL, Fujiwara Y, Handel MA, Carter GW. 2019. Uncoupling of transcriptomic and cytological differentiation in mouse spermatocytes with impaired meiosis. Mol Biol Cell. 30: 717-728. Abstract
Gardner HL, Sivaprakasam K, Briones N, Zismann V, Perdigones N, Drenner K, Facista S, Richholt R, Liang W, Aldrich J, Trent JM, Shields PG, Robinson N, Johnson J, Lana S, Houghton P, Fenger J, Lorch G, Janeway KA, London CA, Hendricks WPD. 2019. Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2. Commun Bio. 2:226. Abstract
Graham LC, Grabowska WA, Chun Y, Risacher SL, Philip VM, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative (ADNI), Sukoff Rizzo SJ, Howell GR. 2019. Exercise prevents obesity-induced cognitive decline and white matter damage in mice. Neurobiol Aging. 80: 154-172. Abstract
Kwong M, Gardner HL, Dieterle N, Rentko V. 2019. Optimization of electronic medical records for data mining using a common data model. Top Companion Anim Med. 37:100364. doi: 10.1016/j.tcam.2019.100364. Abstract
Kwong M, Gardner HL, Dieterle N, Rentko V. 2019. TRANSLATOR Database-A vision for a multi-institutional research network. Top Companion Anim Med.37:100363. doi: 10.1016/j.tcam.2019.100363. Abstract
Londhe P, Gutwillig M, London C. 2019. Targeted therapies in veterinary oncology. Vet Clin North Am Small Anim Pract. Epub ahead of print. Abstract
Neuner SM, Heuer SE, Huentelman MJ, O'Connell KMS, Kaczorowski CC. 2019. Harnessing genetic complexity to enhance translatability of Alzheimer's disease mouse models: A path toward precision medicine. Neuron 101: 399-411. Abstract
Neuner SM, Heuer SE, Zhang JG, Philip VM, Kaczorowski CC. 2019. Identification of pre-symptomatic gene signatures that predict resilience to cognitive decline in the genetically diverse AD-BXD model. Front Genet. 10:35. Abstract
Sarhan J, Liu BC, Muendlein HI, Weindel CG, Smirnova I, Tang AY, Ilyukha V, Sorokin M, Buzdin A, Fitzgerald KA, Poltorak A. 2019. Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death Differ. 26: 332-347. Abstract
Sol A, Lipo E, de Jesús-Díaz DA, Murphy C, Devereux M, Isberg RR. 2019. Legionella pneumophila translocated translation inhibitors are required for bacterial-induced host cell cycle arrest. Proc Natl Acad Sci USA. 116: 3221-3228. Abstract
Williams PA, Braine CE, Kizhatil K, Foxworth NE, Tolman NG, Harder JM, Scott RA, Sousa GL, Panitch A, Howell GR, John SWM. 2019. Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma. Mol Neurodegener. 14: 6. Abstract
2018
Benway CJ, Iacomini J. 2018. Defining a microRNA-mRNA interaction map for calcineurin inhibitor induced nephrotoxicity. Am J Transplant. 8: 796-809. Abstract
Child KM, Herrick DB, Schwob JE, Holbrook EH, Jang W. 2018. The neuroregenerative capacity of olfactory stem cells is not limitless: Implications for aging. J Neurosci. 38: 6806-6824. Abstract
Freytsis M, Baugh L, Liu Z, Georgakoudi I, Hinds PW, Black LD, Huggins GS. 2018. Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation. PLoS One 13: e0190623. Abstract
Gardner HL, Rippy SB, Bear MD, Cronin KL, Heeb H, Burr H, Cannon CM, Penmetsa KV, Viswanadha S, Vakkalanka S, London CA. 2018. Phase I/II evaluation of RV1001, a novel PI3Kδ inhibitor, in spontaneous canine lymphoma. PLoS One 13: e0195357. Abstract
Kulkarni S, Goel S, Sengupta S, Cochran BH. 2018. A large-scale RNAi screen identifies SGK1 as a key survival kinase for GBM stem cells. Mol Cancer Res. 16: 103-114. Abstract
Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A. 2018. Constitutive interferon maintains GBP expression required for release of bacterial components upstream of pyroptosis and anti-DNA responses. Cell Rep. 24: 155-168. Abstract
Montesion M, Bhardwaj N, Williams ZH, Kuperwasser C, Coffin JM. 2018. Mechanisms of HERV-K (HML-2) transcription during human mammary epithelial cell transformation. J Virol. 92: e01258-17. Abstract
Montesion M, Williams ZH, Subramanian RP, Kuperwasser C, Coffin JM. 2018. Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites. Retrovirology 15: 57. Abstract
Neil AJ, Liang MU, Khristich AN, Shah KA, Mirkin SM. 2018. RNA-DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication. Nucleic Acids Res. 46: 3487-3497. Abstract
Sadowski AR, Gardner HL, Borgatti A, Wilson H, Vail DM, Lachowicz J, Manley C, Turner A, Klein MK, Waite A, Sahora A, London CA. 2018. Phase II study of the oral selective inhibitor of nuclear export (SINE) KPT-335 (verdinexor) in dogs with lymphoma. BMC Vet Res. 14: 250. Abstract
Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, Tang AY, Rongvaux A, Bunnell SC, Shao F, Green DR, Poltorak A. 2018. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proc Natl Acad Sci USA. 115: E1088-E10897. Abstract
Sweeney MF, Sonnenschein C, Soto AM. 2018. Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D. Cancer Cell Int. 18: 43. Abstract
2017
Khanna P, Maron JL, Walt DR. 2017. Development of a rapid salivary proteomic platform for oral feeding readiness in the preterm newborn. Front Pediatr. 5: 268. Abstract
McDonald G, Medina CO, Pilichowska M, Kearney JF, Shinkura R, Selsing E, Wortis HH, Honjo T, Imanishi-Kari T. 2017. Accelerated systemic autoimmunity in the absence of somatic hypermutation in 564Igi: A mouse model of systemic lupus with knocked-in heavy and light chain genes. Front Immunol. 8: 1094. Abstract
McGinty RJ, Rubinstein RG, Neil AJ, Dominska M, Kiktev D, Petes TD, Mirkin SM. 2017. Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair. Genome Res. 27: 2072-2082. Abstract
Neil AJ, Kim JC, Mirkin SM. 2017. Precarious maintenance of simple DNA repeats in eukaryotes. Bioessasy 39. doi: 10.1002/bies.201700077. Abstract
Radchenko EA, McGinty RJ, Aksenova AY, Neil AJ, Mirkin SM 2017. Quantitative Analysis of the Rates for Repeat-Mediated Genome Instability in a Yeast Experimental System. Methods Mol Biol. 1672: 421-428. Abstract
Tsutakawa SE, Thompson MJ, Arvai AS, Neil AJ, Shaw SJ, Algasaier SI, Kim JC, Finger LD, Jardine E, Gotham VJB, Sarker AH, Her MZ, Rashid F, Hamdan SM, Mirkin SM, Grasby JA, Tainer JA. 2017. Nat Comm. 8: 15855. Abstract
2016
Graham LC, Harder JM, Soto I, de Vries WN, John SW, Howell GR. 2016. Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease. Sci Rep. 6: 21568. Abstract
Gross K, Wronski A, Skibinski A, Phillips S, Kuperwasser C. 2016. Cell fate decisions during breast cancer development. J Dev Biol. 4: 4. Abstract
Kotewicz KM, Ramabhadran V, Sjoblom N, Vogel JP, Haenssler E, Zhang M, Behringer J, Scheck RA, Isberg RR. 2016. A single Legionella effector catalyzes a multistep ubiquitination pathway to rearrange tubular endoplasmic reticulum for replication. Cell Host Microbe. 21: 169-181. Abstract
Leaderer D, Cashman SM, Kumar-Singh R. 2016. G-quartet oligonucleotide mediated delivery of proteins into photoreceptors and retinal pigment epithelium via intravitreal injection. Exp Eye Res. 145: 380-392. Abstract
Papageorgiou I, Freytsis M, Court MH. 2016. Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver. Biochem Pharmacol. 117: 78-87. Abstract
Shearer AM, Rana R, Austin K, Baleja JD, Nguyen N, Bohm A, Covic L, Kuliopulos A. 2016. Targeting liver fibrosis with a cell-penetrating PAR2 pepducin. J Biol Chem. 291: 23188-23198. Abstract
Speroni L, Sweeney MF, Sonnenschein C, Soto AM. 2016. A hormone-responsive 3D culture model of the human mammary gland epithelium. J Vis Exp. (108): e53098. Abstract
Soto I, Grabowska WA, Onos KD, Graham LC, Jackson HM, Simeone SN, Howell GR. 2016. Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease. Neurobiol Aging 42: 50-60. Abstract
Sweeney MF, Hasan N, Soto AM, Sonnenschein C. 2015. Environmental endocrine disruptors: Effects on the human male reproductive system. Rev Endocr Metab Disord. 16: 341-357. Abstract
Weindel CG, Richey LJ, Mehta AJ, Shah M, Huber BT. 2016. Autophagy in dendritic cells and B cells is critical for the inflammatory state of TLR7-mediated autoimmunity. J Immunol. 198: 1081-1092. Abstract
Wildschutte JH*, Williams ZH*, Montesion M, Subramanian RP, Kidd JM, Coffin JM. 2016. Discovery of unfixed endogenous retrovirus insertions in diverse human populations. Proc Natl Acad Sci USA 113: E2326-E2334. (* equal contribution) Abstract
2015
Bhardwaj N, Montesion M, Roy F, Coffin JM. 2015. Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1. Viruses 7: 939-968. Abstract
Gilbert MA, Lin B, Peterson J, Jang W, Schwob JE. 2015. Neuregulin1 and ErbB expression in the uninjured and regenerating olfactory mucosa. Gene Exp Patterns 19: 108-119. Abstract
Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA, Slonim DK, Bianchi DW. 2015. The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. Am J Med Genet A. 167: 1993-2008. Abstract
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. 2015. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 212: 287-295. Abstract
Jackson HM, Onos KD, Pepper KW, Graham LC, Akeson EC, Byers C, Reinholdt LG, Frankel WN, Howell GR. 2015. DBA/2J Genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. PLoS One 10: e0125897. Abstract
Jain S, Chen J, Nicolae A, Wang H, Shin DM, Adkins EB, Sproule TJ, Leeth CM, Sakai T, Kovalchuk AL, Raffeld M, Ward JM, Rehg JE, Waldmann TA, Jaffe ES, Roopenian DC, Morse HC 3rd. 2015. Am J Pathol. 185: 3102-3114. Abstract
Khanna P, Walt DR. 2015. Salivary diagnostics using a portable point-of-service platform: A review. Clin Ther. 37: 498-504. Abstract
Leaderer D, Cashman SM, Kumar-Singh R. 2015. Adeno-associated virus mediated delivery of an engineered protein that combines the complement inhibitory properties of CD46, CD55 and CD59. J Gene Med. 17: 101-115. Abstract
Leaderer D, Cashman SM, Kumar-Singh R. 2015. Topical application of a G-quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration. Exp Eye Res. 140: 171-178. Abstract
Luo C, Pietruska JR, Sheng J, Bronson RT, Hu MG, Cui R, Hinds PW. 2015. Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo. Pigment Cell Melanoma Res. 28: 603-606. Abstract
Mazumdar S, Arendt LM, Phillips S, Sedic M, Kuperwasser C, Gill G. 2015. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS One 10: e0121281. Abstract
McDonald G, Cabal N, Vannier A, Umiker B, Yin RH, Orjalo AV Jr, Johansson HE, Han JH, Imanishi-Kari T. 2015. Female bias in systemic lupus erythematosus is associated with the differential expression of X-linked Toll-like receptor 8. Front Immunol. 6: 457. Abstract
Soto I, Graham LC, Richter HJ, Simeone SN, Radell JE, Grabowska W, Funkhouser WK, Howell MC, Howell GR. 2015. APOE stabilization by exercise prevents aging neurovascular dysfunction and complement induction. PLoS Biol. 13: e1002279. Abstract
Sun X, Pinacho R, Saia G, Punko D, Meana JJ, Ramos B, Gill G. 2015. Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning. Dev Neurobiol. 75: 93-108. Abstract
Weindel CG, Richey LJ, Bolland S, Mehta AJ, Kearney JF, Huber BT. 2015. B cell autophagy mediates TLR7-dependent autoimmunity and inflammation. Autophagy 11: 1010-1024. Abstract
Yuan J, Benway CJ, Bagley J, Iacomini J. 2015. MicroRNA-494 promotes cyclosporine-induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN. Am J Transplant. 15: 1682-1691. Abstract